Why do I feel worse on TRT despite high testosterone levels and no AI?

It is common to feel a 'honeymoon' surge in the first two weeks as exogenous testosterone adds to your natural production before your own system shuts down. If your levels are very high and you aren't using an AI, your estradiol may have spiked, or your dose might simply be too high for your body to maintain stable neurotransmitter balance. At HeydayMD, we focus on finding the 'sweet spot' where symptoms resolve without over-relying on ancillary medications, ensuring your protocol is sustainable for the long term.