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🩸 Blood Work

Long-term TRT users: what happened to your cholesterol and lipid panels over the years?

Asked in r/trt · Answered by the HeydayMD team ·

I know everyone checks lipids right after starting, but I'm curious what happens to HDL, LDL, and total cholesterol after 3, 5, or more years on TRT.

The short answer

Long-term testosterone replacement therapy can frequently cause modest reductions in HDL (the "good" cholesterol) and shifts in LDL depending on your baseline metabolic health and delivery method. While these changes are often manageable, tracking multi-year trends is crucial rather than just relying on the initial post-start lab check. At HeydayMD, our ongoing telehealth management includes comprehensive annual cardiovascular tracking to ensure your lipid panels stay healthy while your hormone levels remain optimized.

Every body is different. A licensed provider can look at your own labs and symptoms.

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The information on this page is for educational purposes only and is not medical advice. Questions are paraphrased from public Reddit discussions, which are linked for reference — HeydayMD is not affiliated with Reddit. Answers are general education written by the HeydayMD team, not individual guidance. Always talk to a licensed healthcare provider before making treatment decisions.